Frédéric Calon

• Centre de recherche du CHU de Québec - Université Laval
• Centre Nutrition, santé et société
• Centre thématique de recherche en neurosciences
• Institut sur la nutrition et les aliments fonctionnels
• Institut sur le vieillissement et la participation sociale des aînés

• Rosalie Cottez, Maîtrise en sciences pharmaceutiques - avec mémoire
• Gabriel Boulay, Doctorat en sciences pharmaceutiques
• Paul Louis Alexis Pillet, Maîtrise en sciences pharmaceutiques - avec mémoire
• Paul Louis Alexis Pillet, Doctorat en sciences pharmaceutiques
• Josue Valentin Escalera, Doctorat en sciences pharmaceutiques
• Sabrine Linhares, Doctorat en sciences pharmaceutiques
• Emma Glajean, Doctorat en sciences pharmaceutiques
• Léa Otaegui, Stage postdoctoral en neurobiologie

Encadrements terminés dans les 5 dernières années

• Olivier Landry, Doctorat en sciences pharmaceutiques
• Sabrine Linhares, Maîtrise en sciences pharmaceutiques - avec mémoire
• Patrick Blondin Tsafack, Maîtrise en sciences pharmaceutiques - avec mémoire
• Solène Pradeloux, Doctorat en sciences pharmaceutiques
• Louise Reveret, Doctorat en sciences pharmaceutiques
• Méryl Farelle Oye Mintsa Mi Mba, Doctorat en sciences pharmaceutiques
• Emilie Wong Chong, Doctorat en médecine moléculaire
• Laura Pshevorskiy, Maîtrise en sciences pharmaceutiques - avec mémoire
• Manon Leclerc, Doctorat en sciences pharmaceutiques
• Katherine Picard, Doctorat en médecine moléculaire
• Solène Pradeloux, Maîtrise en sciences pharmaceutiques - avec mémoire
• Louise Reveret, Maîtrise en sciences pharmaceutiques - avec mémoire

Publications des 5 dernières années

Natural Health Products for Symptomatic Relief of Parkinson's Disease: Prevalence, Interest, and Awareness., Journal of Parkinson's disease, 2024. Diadhiou S, Maas BR, Schootemeijer S, Bloem BR, de Vries NM, Calon F, Darweesh SKL, de Rus Jacquet A. , DOI 10.3233/jpd-240102

Aging, sex, metabolic and life experience factors: Contributions to neuro-inflammaging in Alzheimer's disease research., Neuroscience and biobehavioral reviews, 2024. Singhaarachchi PH, Antal P, Calon F, Culmsee C, Delpech JC, Feldotto M, Geertsema J, Hoeksema EE, Korosi A, Layé S, McQualter J, de Rooij SR, Rummel C, Slayo M, Sominsky L, Spencer SJ. , DOI 10.1016/j.neubiorev.2024.105724

Age-dependent impact of streptozotocin on metabolic endpoints and Alzheimer's disease pathologies in 3xTg-AD mice., Neurobiology of disease, 2024. Canet G, Gratuze M, Zussy C, Bouali ML, Diaz SD, Rocaboy E, Laliberté F, El Khoury NB, Tremblay C, Morin F, Calon F, Hébert SS, Julien C, Planel E. , DOI 10.1016/j.nbd.2024.106526

Cerebrospinal fluid soluble insulin receptor levels in Alzheimer's disease., Alzheimer's & dementia (Amsterdam, Netherlands), 2024. Thomas P, Leclerc M, Evitts K, Brown C, Miller W, Hanson AJ, Banks WA, Gibbons L, Domoto-Reilly K, Jayadev S, Li G, Peskind E, Young JE, Consortium for the early identification of Alzheimer's disease‐Quebec (CIMA‐Q), Calon F, Rhea EM. , DOI 10.1002/dad2.12603

Lower GLUT1 and unchanged MCT1 in Alzheimer's disease cerebrovasculature., Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2024. Leclerc M, Tremblay C, Bourassa P, Schneider JA, Bennett DA, Calon F. , DOI 10.1177/0271678x241237484

Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson's disease., Neural regeneration research, 2024. Kerdiles O, Oye Mintsa Mi-Mba MF, Coulombe K, Tremblay C, Émond V, Saint-Pierre M, Rouxel C, Berthiaume L, Julien P, Cicchetti F, Calon F. , DOI 10.4103/nrr.nrr-d-23-00595

Pre-operative levels of angiopoietin protein-like 3 (ANGPTL3) in women diagnosed with high-grade serous carcinoma of the ovary., Lipids in health and disease, 2024. Wong Chong E, Joncas FH, Douville P, Bachvarov D, Diorio C, Calon F, Bergeron AC, Blais J, Leung SOA, Seidah NG, Gangloff A. , DOI 10.1186/s12944-024-02038-8

High-Fat Diets in Animal Models of Alzheimer's Disease: How Can Eating Too Much Fat Increase Alzheimer's Disease Risk?, Journal of Alzheimer's disease : JAD, 2024. Valentin-Escalera J, Leclerc M, Calon F. , DOI 10.3233/jad-230118

Higher angiotensin-converting enzyme 2 (ACE2) levels in the brain of individuals with Alzheimer's disease., Acta neuropathologica communications, 2023. Reveret L, Leclerc M, Emond V, Tremblay C, Loiselle A, Bourassa P, Bennett DA, Hébert SS, Calon F. , DOI 10.1186/s40478-023-01647-1

How nutrients and natural products act on the brain: Beyond pharmacology., Cell reports. Medicine, 2023. de Rus Jacquet A, Layé S, Calon F. , DOI 10.1016/j.xcrm.2023.101243

State of the Science on Brain Insulin Resistance and Cognitive Decline Due to Alzheimer's Disease., Aging and disease, 2023. Rhea EM, Leclerc M, Yassine HN, Capuano AW, Tong H, Petyuk VA, Macauley SL, Fioramonti X, Carmichael O, Calon F, Arvanitakis Z. , DOI 10.14336/ad.2023.0814

Pharmacokinetics, biodistribution and toxicology of novel cell-penetrating peptides, Scientific Reports, 2023. L. Reveret, M. Leclerc, F. Morin, V. Émond, F. Calon. DOI 10.1038/s41598-023-37280-0

Sex and Age Differences in a Progressive Synucleinopathy Mouse Model, Biomolecules, 2023. Jérôme Lamontagne-Proulx, Katherine Coulombe, Marc Morissette, Marie Rieux, Frédéric Calon, Thérèse Di Paolo, Denis Soulet. DOI 10.3390/biom13060977

Postsynaptic protein Shank3a deficiency synergizes with Alzheimer's disease neuropathology to impair cognitive performance in the 3xTg-AD murine model., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. Landry O, François A, Oye Mintsa Mi-Mba MF, Traversy MT, Tremblay C, Emond V, Bennett DA, Gylys KH, Buxbaum JD, Calon F. , DOI 10.1523/jneurosci.1945-22.2023

Cerebrovascular insulin receptors are defective in Alzheimer’s disease, Brain, 2023. Manon Leclerc, Philippe Bourassa, Cyntia Tremblay, Vicky Caron, Camille Sugère, Vincent Emond, David A Bennett, Frédéric Calon. DOI 10.1093/brain/awac309

Investigating the plasma-liver-brain axis of omega-3 fatty acid metabolism in mouse knock-in for the human apolipoprotein E epsilon 4 allele, Journal of Nutritional Biochemistry, 2023. Husain, M.A., Vachon, A., Chouinard-Watkins, R., Vandal, M., Calon, F., Plourde, M.. DOI 10.1016/j.jnutbio.2022.109181

Direct and Indirect Effects of Filamin A on Tau Pathology in Neuronal Cells, Molecular Neurobiology, 2023. Levert, S., Pilliod, J., Aumont, É., Armanville, S., Tremblay, C., Calon, F., Leclerc, N.. DOI 10.1007/s12035-022-03121-w

Evidence of Filamin A loss of solubility at the prodromal stage of neuropathologically-defined Alzheimer's disease., Frontiers in aging neuroscience, 2022. Aumont E, Tremblay C, Levert S, Bennett DA, Calon F, Leclerc N. , DOI 10.3389/fnagi.2022.1038343

Inhibition of PLK2 activity affects APP and tau pathology and improves synaptic content in a sex-dependent manner in a 3xTg mouse model of Alzheimer's disease., Neurobiology of disease, 2022. Frédéric Calon. , DOI 10.1016/j.nbd.2022.105833

Risk of Neutropenia in Adults Treated with Piperacillin-Tazobactam or Cefazolin: A Retrospective Cohort Study., The Canadian journal of hospital pharmacy, 2022. Frédéric Calon. , DOI 10.4212/cjhp.3161

Sauna-like conditions or menthol treatment reduce tau phosphorylation through mild hyperthermia., Neurobiology of aging, 2022. Frédéric Calon. , DOI 10.1016/j.neurobiolaging.2022.02.011

Circulating levels of PCSK9, ANGPTL3 and Lp(a) in stage III breast cancers, BMC Cancer, 2022. Wong Chong, E., Joncas, F.-H., Seidah, N.G., Calon, F., Diorio, C., Gangloff, A.. DOI 10.1186/s12885-022-10120-6

Combining NGN2 programming and dopaminergic patterning for a rapid and efficient generation of hiPSC-derived midbrain neurons, Scientific Reports, 2022. Sheta, R., Teixeira, M., Idi, W., Pierre, M., de Rus Jacquet, A., Emond, V., Zorca, C.E., Vanderperre, B., Durcan, T.M., Fon, E.A., Calon, F., Chahine, M., Oueslati, A.. DOI 10.1038/s41598-022-22158-4

Effect of Docosahexaenoic Acid (DHA) at the Enteric Level in a Synucleinopathy Mouse Model. , Nutrients, 2021. Frédéric Calon. , DOI 10.3390/nu13124218

Role of Retinoid X Receptors (RXRs) and dietary vitamin A in Alzheimer's disease: Evidence from clinicopathological and preclinical studies., Neurobiology of disease, 2021. Frédéric Calon. , DOI 10.1016/j.nbd.2021.105542

Diet enriched in omega-3 fatty acids alleviates olfactory system deficits in APOE4 transgenic mice., The European journal of neuroscience, 2021. Frédéric Calon. , DOI 10.1111/ejn.15472

Metabolic determinants of Alzheimer's disease: A focus on thermoregulation., Ageing research reviews, 2021. Frédéric Calon. , DOI 10.1016/j.arr.2021.101462

Repurposing beta-3 adrenergic receptor agonists for Alzheimer's disease: beneficial effects in a mouse model., Alzheimer's research & therapy, 2021. , DOI 10.1186/s13195-021-00842-3

Targeting TDP-43 Pathology Alleviates Cognitive and Motor Deficits Caused by Chronic Cerebral Hypoperfusion., Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2021. , DOI 10.1007/s13311-021-01015-8

Can Natural Products Exert Neuroprotection without Crossing the Blood-Brain Barrier? , International journal of molecular sciences, 2021. Frédéric Calon. , DOI 10.3390/ijms22073356

Beta-amyloid pathology in human brain microvessel extracts from the parietal cortex: relation with cerebral amyloid angiopathy and Alzheimer's disease, ACTA NEUROPATHOLOGICA, 2021. Frédéric Calon. DOI 10.1007/s00401-019-01967-4