Caroline Sirois

• Centre de recherche du CHU de Québec - Université Laval
• Centre de recherche en données massives
• Institut sur le vieillissement et la participation sociale des aînés
• VITAM - Centre de recherche en santé durable (Reconnu FRQ - secteur santé)

• Mélanie Carrier, Maîtrise en sciences pharmaceutiques - avec mémoire
• Bryan Quesnel, Maîtrise en épidémiologie - avec mémoire
• Alexandre Campeau Calfat, Doctorat en sciences pharmaceutiques - pharmaco-épidémiologie
• Cécile Duval, Doctorat en épidémiologie
• Moussa Sana, Doctorat en santé publique et communautaire
• Husein Smayli, Maîtrise en épidémiologie - épidémiologie clinique - avec mémoire
• Marie-Eve Gagnon, Doctorat en sciences pharmaceutiques - pharmaco-épidémiologie
• Myriam Khelifi, Maîtrise en sciences pharmaceutiques - pharmaco-épidémiologie - avec mémoire

Encadrements terminés dans les 5 dernières années

• Charles-Antoine Guay, Doctorat en épidémiologie
• Antarou Ly, Doctorat en épidémiologie
• Marc Simard, Doctorat en épidémiologie
• Houssem Missaoui, Maîtrise en sciences pharmaceutiques - pharmaco-épidémiologie - avec mémoire
• Awa Diop, Doctorat en biostatistique
• Maude Gosselin, Maîtrise en santé publique - avec mémoire
• Annie Maltais, Maîtrise en épidémiologie - avec mémoire

Publications des 5 dernières années

Polypharmacy Thresholds that Best Predict Emergency Room Visits and Mortality in Older Adults: A Population-Based Study in Québec, Canada, Journal of Applied Gerontology, 2026. Alexandre Campeau Calfat, Justin P. Turner, Marc Simard, Marjolaine Dubé, Caroline Sirois. DOI 10.1177/07334648251391524

Polypharmacie et déprescription en milieu rural: étude qualitative auprès de personnes aînées et de personnes proches aidantes au Québec, Canadian Journal on Aging / La Revue canadienne du vieillissement, 2026. Caroline Sirois, Anne-Sophie Bergeron, Anne-Frédérique Beaudry, Nicole Ouellet. DOI 10.1017/S071498082610066X

Opioid Prescribing Patterns After Pediatric Adenotonsillectomy: A Bayesian Analysis of a Cross-Sectional Survey of Otolaryngologists in Canada, Journal of Otolaryngology - Head & Neck Surgery, 2026. Hussein Smaily, Pierre-Hugues Carmichael, Caroline Sirois. DOI 10.1177/19160216261425531

Patients’ attitudes towards deprescribing disease modifying anti-rheumatic drugs in rheumatoid arthritis, Patient Education and Counseling, 2026. Lauren Fraser, Michael D. Wiese, Nagham Ailabouni, Lisa Kalisch Ellett, Caroline Sirois, William Berthelot, Susanna M. Proudman, Leah McWilliams, Emily Reeve. DOI 10.1016/j.pec.2025.109432

Effectiveness of a pharmacist-led deprescribing intervention in older inpatients: an implementation study with retrospective control group, European Geriatric Medicine, 2026. Marci Dearing, Susan K. Bowles, Jennifer E. Isenor, Kristie Rebecca Weir, Lisa Kouladjian O’Donnell, Olga Kits, Sarah N. Hilmer, Heather Neville, Kenneth Rockwood, Caroline Sirois, Mohammad Hajizadeh, Kent Toombs, Aprill Susin, Emily Reeve. DOI 10.1007/s41999-025-01371-0

Polypharmacy Thresholds that Best Predict Emergency Room Visits and Mortality in Older Adults: A Population-Based Study in Québec, Canada, Journal of Applied Gerontology, 2025. Alexandre Campeau Calfat, Justin P. Turner, Marc Simard, Marjolaine Dubé, Caroline Sirois. DOI 10.1177/07334648251391524

Patterns of intentional overdoses in young patients: a retrospective cohort study in Québec, Canada (2020-2022), Paediatrics & Child Health, 2025. Audrée Elliott, Isabelle Bilodeau, Caroline Sirois, Maude St-Onge. DOI 10.1093/pch/pxaf017

Patterns and determinants of statin prescribing and discontinuation in individuals aged 80 and older: A 10-year population-based cohort study, Journal of the American Pharmacists Association, 2025. Myriam Khelifi, Marc Simard, Véronique Boiteau, Marie-Eve Gagnon, Olivia Dalleur, Caroline Sirois. DOI 10.1016/j.japh.2025.102445

Cost trends of potentially inappropriate medications among older adults between 2012 and 2021 in Quebec, Canada: a population-based repeated cross-sectional study, BMC Geriatrics, 2025. Magalie Gagnon, Jason Robert Guertin, Caroline Sirois, Marc Simard, Benoît Cossette, Marie-Eve Gagnon. DOI 10.1186/s12877-025-06235-7

Combined impact of the COVID-19 pandemic and the number of comorbidities on community antibiotic utilisation rates: a population-based retrospective cohort study using linked health administrative data in Quebec, Canada, BMJ Open, 2025. Patrick Fortin, Élise Fortin, Caroline Sirois, Caroline Quach, Marc Simard, Nadine Magali-Ufitinema, Chantal Sauvageau. DOI 10.1136/bmjopen-2024-096283

Pharmaceuticals in drinking water: a scoping review to raise pharmacists’ public health and environmental awareness on contamination in groundwater, surface water, and other sources, International Journal of Pharmacy Practice, 2025. Mandy Coderre, Ann-Sophie Fortin, Louis-David Morency, Juliette Roy, Caroline Sirois. DOI 10.1093/ijpp/riaf038

Trends in Drug Claims for Non‐Specific Low Back Pain in Québec, 1997 to 2018, Musculoskeletal Care, 2025. Antarou Ly, Caroline Sirois, Clermont E. Dionne. DOI 10.1002/msc.70084

Deprescribed or Discontinued? Addressing Terminology Misinterpretation in Research, Basic & Clinical Pharmacology & Toxicology, 2025. Caroline Sirois, Alexandre Campeau Calfat, Justin P. Turner. DOI 10.1111/bcpt.70054

Billing Deprescribing Interventions: Portrait of an Initiative in Québec, Canada, Basic & Clinical Pharmacology & Toxicology, 2025. Alexandre Campeau Calfat, Maude Gosselin, Caroline Sirois. DOI 10.1111/bcpt.70050

The association between polypharmacy and disease control in rheumatoid arthritis and systemic lupus erythematosus: a cohort study, Rheumatology International, 2025. William Berthelot, Caroline Sirois, Anne-Sophie Julien, Nathalie Amiable, Louis Bessette, Philippe Desaulniers, Marie-Claude Audet, Sonia Lagacé, Paul R. Fortin. DOI 10.1007/s00296-025-05804-8

Association between number of medications and indicators of potentially inappropriate polypharmacy: a population-based cohort of older adults in Quebec, Canada, Therapeutic Advances in Drug Safety, 2024. Alexandre Campeau Calfat, Justin P. Turner, Marc Simard, Véronique Boiteau, Caroline Sirois. DOI 10.1177/20420986241309882

A comparative analysis of medication counting methods to assess polypharmacy in medico-administrative databases, Research in Social and Administrative Pharmacy, 2024. Marie-Eve Gagnon, Miceline Mésidor, Marc Simard, Yohann M. Chiu, Maude Gosselin, Bernard Candas, Caroline Sirois. DOI 10.1016/j.sapharm.2024.05.006

Do machine learning methods Make Better predictions in pharmacoepidemiology?, Annals of Epidemiology, 2024. Ana Paula Pena-Gralle, Mireille E. Schnitzer, Sofia-Nada Boureguaa, Félix Morin, Marc-André Legault, Caroline Sirois, Alice Dragomir, Lucie Blais. DOI 10.1016/j.annepidem.2024.07.010

Medication Use Around the Diagnosis of Alzheimer's Disease: A Commentary on the Study by Liau et al, Journal of the American Medical Directors Association, 2024. Caroline Sirois, Marc Simard. DOI 10.1016/j.jamda.2024.105103

Evidence‐based data for newly approved medications' use in older adults: An analysis from clinical trials to monographs, Journal of the American Geriatrics Society, 2024. Maude Gosselin, Marie‐Laure Baroud, Odélie‐Rose Denis, Marie‐Eve Gagnon, Caroline Sirois. DOI 10.1111/jgs.18772

Effect of statin use for the primary prevention of cardiovascular disease among older adults: a cautionary tale concerning target trials emulation, Journal of Clinical Epidemiology, 2024. Miceline Mésidor, Caroline Sirois, Jason Robert Guertin, Mireille E. Schnitzer, Bernard Candas, Claudia Blais, Benoit Cossette, Paul Poirier, James M. Brophy, Lisa Lix, Mina Tadrous, Awa Diop, Denis Hamel, Denis Talbot. DOI 10.1016/j.jclinepi.2024.111284

Understanding the Extent of Polypharmacy and its Association With Health Service Utilization Among Persons With Cancer and Multimorbidity: A Population-Based Retrospective Cohort Study in Ontario, Canada, Journal of Pharmacy Practice, 2024. Tamara Dean, Anna Koné, Lynn Martin, Joshua Armstrong, Caroline Sirois. DOI 10.1177/08971900221117105

How does deprescribing (not) reduce mortality? A review of a meta‐analysis in community‐dwelling older adults casts uncertainty over claimed benefits, Basic & Clinical Pharmacology & Toxicology, 2024. Caroline Sirois, Maude Gosselin, Camille Laforce, Marie‐Eve Gagnon, Denis Talbot. DOI 10.1111/bcpt.13921

A bootstrap approach for evaluating uncertainty in the number of groups identified by latent class growth models 2023. Miceline Mésidor, Marc Simard, Caroline Sirois, Denis Talbot. DOI 10.1093/aje/kwad148

Classifying Polypharmacy According to Pharmacotherapeutic and Clinical Risks in Older Adults: A Latent Class Analysis in Quebec, Canada, Drugs & Aging, 2023. M. Gosselin, D. Talbot, M. Simard, Y. M. Chiu, M. Mésidor, V. Boiteau, P.-H. Carmichael, C. Sirois. DOI 10.1007/s40266-023-01028-2

Multimorbidity Treatment Burden Questionnaire (MTBQ): Translation, Cultural Adaptation, and Validation in French-Canadian, Canadian Journal on Aging / La Revue canadienne du vieillissement, 2023. Line Guénette, Véronique Turcotte, Laurianne Bélanger, Lucie Blais, Caroline Sirois, Carlotta Lunghi, Polly Duncan. DOI 10.1017/S0714980822000058

An Alternative Perspective on the Robust Poisson Method for Estimating Risk or Prevalence Ratios, Epidemiology, 2023. Denis Talbot, Miceline Mésidor, Yohann Chiu, Marc Simard, Caroline Sirois. DOI 10.1097/EDE.0000000000001544

Reorganizing Pharmaceutical Care in Family Medicine Groups for Older Adults With or at Risk of Major Neurocognitive Disorders: Protocol for a Mixed Methods Study, JMIR Research Protocols, 2022. Line Guénette, Edeltraut Kröger, Dylan Bonnan, Anne Maheu, Michèle Morin, Laurianne Bélanger, Isabelle Vedel, Machelle Wilchesky, Caroline Sirois, Etienne Durand, Yves Couturier, Nadia Sourial, Clémence Dallaire. DOI 10.2196/42577

Prescribing and deprescribing in very old age: perceptions of very old adults, caregivers and health professionals, Age and Ageing, 2022. Nicole Ouellet, Anne-Sophie Bergeron, Eric Gagnon, Benoit Cossette, Cory A Labrecque, Caroline Sirois. DOI 10.1093/ageing/afac244

Reorganizing pharmaceutical care in family medicine groups for seniors with or at risk of major neurocognitive disorders: protocol for a mixed-methods study (Preprint) 2022. Line Guénette, Edeltraut Kröger, Dylan Bonnan, Anne Maheu, Michèle Morin, Laurianne Bélanger, Isabelle Vedel, Machelle Wilchesky, Caroline Sirois, Étienne Durand, Yves Couturier, Nadia Sourial. DOI 10.2196/preprints.42577

Attitudes Toward Deprescribing in Older Adults and Caregivers: A Survey in Quebec, Canada, Journal of Applied Gerontology, 2022. Bianca Rakheja, Caroline Sirois, Nicole Ouellet, Barbara Roux, Marie-Laure Laroche. DOI 10.1177/07334648211069553

Exploring the associations between polypharmacy and COVID-19-related hospitalisations and deaths: a population-based cohort study among older adults in Quebec, Canada, BMJ Open, 2022. Caroline Sirois, Véronique Boiteau, Yohann Chiu, Rodica Gilca, Marc Simard. DOI 10.1136/bmjopen-2021-060295

Health Impacts and Characteristics of Deprescribing Interventions in Older Adults: Protocol for a Systematic Review and Meta-analysis, JMIR Research Protocols, 2021. Zoë Tremblay, David Mumbere, Danielle Laurin, Caroline Sirois, Daniela Furrer, Lise Poisblaud, Pierre-Hugues Carmichael, Barbara Farrell, André Tourigny, Anik Giguere, Isabelle Vedel, José Morais, Edeltraut Kröger. DOI 10.2196/25200

Exploring polypharmacy with artificial intelligence: data analysis protocol, BMC Medical Informatics and Decision Making, 2021. Caroline Sirois, Richard Khoury, Audrey Durand, Pierre-Luc Deziel, Olga Bukhtiyarova, Yohann Chiu, Denis Talbot, Alexandre Bureau, Philippe Després, Christian Gagné, François Laviolette, Anne-Marie Savard, Jacques Corbeil, Thierry Badard, Sonia Jean, Marc Simard. DOI 10.1186/s12911-021-01583-x

Mapping of drug-related problems among older adults conciliating medical and pharmaceutical approaches, European Geriatric Medicine, 2021. Marie-Laure Laroche, Thi Hong Van Ngo, Caroline Sirois, Amélie Daveluy, Michel Guillaumin, Marie-Blanche Valnet-Rabier, Muriel Grau, Barbara Roux, Louis Merle. DOI 10.1007/s41999-021-00482-8

Clinical services in community pharmacies: a scoping review of policy and social implications, International Journal of Pharmacy Practice, 2021. Alexandre Campeau Calfat, Cécile Duval, Maude Laberge, Anne-Marie Savard, Caroline Sirois. DOI 10.1093/ijpp/riaa007

Does socio-economic status influence the effect of multimorbidity on the frequent use of ambulatory care services in a universal healthcare system? A population-based cohort study, BMC Health Services Research, 2021. Mbuya-Bienge, C., Simard, M., Gaulin, M., Candas, B., Sirois, C.. DOI 10.1186/s12913-021-06194-w

Health professionals' perspectives regarding polypharmacy in older patients with cancer: A mixed-design exploratory study, Journal of Geriatric Oncology, 2021. Sirois, C., Turner, J.P., Hébert, J.. DOI 10.1016/j.jgo.2021.02.027

La déprescription : réponses aux questions !, Regroupement des pharmaciens experts en gériatrie de l’Association des pharmaciens en établissements de santé du Québec, 2021.

Étudier la polypharmacie avec l’intelligence artificielle, Événement TechSanté, la Semaine numériQc, 2021.

La déprescription en psychiatrie chez le sujet vieillissant, Colloque de Santé Mentale, 2021.

A New Care Model Reduces Polypharmacy and Potentially Inappropriate Medications in Long-Term Care, Journal of the American Medical Directors Association, 2021. Garland, C.T., Guénette, L., Kröger, E., Carmichael, P.-H., Rouleau, R., Sirois, C.. DOI 10.1016/j.jamda.2020.09.039