Alexandre Caron

• Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (Affilié à l’Université Laval)
• Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (Reconnu FRQ - secteur santé)
• Centre thématique de recherche en neurosciences

• Soumia Fenni, Maîtrise en sciences pharmaceutiques - avec mémoire
• Axelle Khouma, Doctorat en sciences pharmaceutiques
• Luce-Marie Loumou, Maîtrise en sciences pharmaceutiques - avec mémoire
• Fatima Hjeij, Doctorat en médecine moléculaire
• Zoé Jargaille, Maîtrise en médecine moléculaire - avec mémoire
• Wandy Idris, Maîtrise en sciences pharmaceutiques - avec mémoire
• Laura Tribouillard, Doctorat en médecine moléculaire
• Olivier Lavoie, Doctorat en sciences pharmaceutiques
• Camille Beets, Doctorat en sciences pharmaceutiques

Encadrements terminés dans les 5 dernières années

• Sarra Beji, Doctorat en sciences pharmaceutiques
• Moein Minbashi Moeini, Doctorat en sciences pharmaceutiques
• Olivier Lavoie, Maîtrise en sciences pharmaceutiques - avec mémoire
• Bernie Efole Bibi Kabong, Doctorat en sciences pharmaceutiques
• Audrey Turmel, Maîtrise en sciences pharmaceutiques - avec mémoire
• Haneyeh Amidi, Maîtrise en nutrition - avec mémoire
• Anisia Judith da Costa e Silva, Doctorat en sciences pharmaceutiques
• Sarra Beji, Maîtrise en sciences pharmaceutiques - avec mémoire
• Bernie Efole Bibi Kabong, Maîtrise en sciences pharmaceutiques - avec mémoire
• Jordan Grondin, Maîtrise en sciences pharmaceutiques - avec mémoire
• Nader Srour, Doctorat en sciences pharmaceutiques
• Charles Colas, Doctorat en médecine moléculaire

Publications des 5 dernières années

Dietary protein source dictates the impact of obesogenic diets on hepatic steatosis and insulin resistance via carnitine-dependent regulation of acetyl-CoA carboxylase 2026. Frederic Begin, William Gagnon, Lia Rossi Perazza, Patricia L Mitchell, Thomas Guerbette, Bertrand Bouchard, Michaël Shum, Alexandre Caron, Christine Des Rosiers, Stanislaw Deja, Phillip J. White, André Marette. DOI 10.64898/2026.06.25.732886

Proanthocyanidin-Rich Cranberry Extract Lowers Glycemia in Established Obesity by Delaying Glucose Absorption., FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. Beji S, Mouchiroud M, Tribouillard L, Efole B, Perazza L, Favereaux L, Poirier A, Idris W, Gélinas Y, Varin TV, Rovère C, Anhê FF, Picard F, Laplante M, Marette A, Michaud A, Caron A. , DOI 10.1096/fj.202601382r

Cold exposure remodels bile acid metabolism in a mouse strain- and tissue-specific manner, Biochemical Journal, 2026. Sarra Beji, Mathilde Mouchiroud, Bernie Efole, Yves Gélinas, Mélanie Verreault, Jocelyn Trottier, Andréanne Michaud, Olivier Barbier, Alexandre Caron. DOI 10.1042/BCJ20260006

Noradrenergic inhibition of definitive POMC neurons through direct and indirect mechanisms, Journal of Neuroendocrinology, 2026. Olivier Lavoie, Audrey Turmel, Axelle Khouma, Moein Minbashi Moeini, Chen Liu, Natalie J. Michael, Alexandre Caron. DOI 10.1111/jne.70169

Impact of nesting materials on energy balance in male C57BL/6J mice exposed to different ambient temperatures, American Journal of Physiology-Endocrinology and Metabolism, 2026. Sarra Beji, Mylène Bastien, Alexandre Caron. DOI 10.1152/ajpendo.00031.2026

GLP-1 Is Not Enough: Can Glucagon Fill the Energy Expenditure Gap?, Neuroendocrinology, 2026. Sarra Beji, Alexandre Caron. DOI 10.1159/000550812

Thermoregulatory adaptations to cold in C3H/HeJ mice are independent of ADRB3 signaling., Scientific reports, 2026. Beji S, Mouchiroud M, Gélinas Y, Laplante M, Michaud A, Caron A. , DOI 10.1038/s41598-026-38538-z

Integrative genetic and liver transcriptomic analyses identify TRIB1AL as a target for steatotic liver disease., The Journal of clinical endocrinology and metabolism, 2026. Gobeil É, Bourgault J, Gagnon E, Samson N, Ruel LJ, Côté V, Mitchell PL, Gotti C, Roux-Dalvai F, Droit A, Bossé Y, Mathieu P, Lajeunesse-Trempe F, Vohl MC, Caron A, Tchernof A, Thériault S, Laplante M, Arsenault BJ. , DOI 10.1210/clinem/dgag043

Galanin Inhibits Histaminergic Neurons via Galanin Receptor 1, eneuro, 2026. Axelle Khouma, Albane Chabot-Chartier, Julie Plamondon, Alexandre Caron, Natalie J. Michael. DOI 10.1523/ENEURO.0420-25.2026

Topiramate Enhances GABAergic Tone to Orexigenic Neuropeptide Y/Agouti‐Related Peptide (NPY/AgRP) Neurons, Obesity, 2026. Moein Minbashi Moeini, Olivier Lavoie, Alexandre Caron, Kevin W. Williams, Natalie J. Michael. DOI 10.1002/oby.70051

Loss of hepatic alpha-1b adrenoceptor exacerbates inflammation and stellate cell activation in diet-induced MASLD., American journal of physiology. Gastrointestinal and liver physiology, 2025. Efole B, Beji S, Mouchiroud M, Gélinas Y, Canivet C, Trottier J, Serdjebi C, Elmquist JK, Deslauriers J, Barbier O, Caron A. , DOI 10.1152/ajpgi.00143.2025

Changes in hypothalamic subunits volume and their association with metabolic parameters and gastrointestinal appetite-regulating hormones following bariatric surgery., Imaging neuroscience (Cambridge, Mass.), 2025. Lachance A, Daoust J, Pelletier M, Caron A, Carpentier AC, Biertho L, Maranzano J, Tchernof A, Dadar M, Michaud A. , DOI 10.1162/imag.a.970

Automated quantification of collagen proportionate area correlates with molecular and histological markers of fibrosis in CCl4-treated rats., Experimental and molecular pathology, 2025. Efole B, Mouchiroud M, Dubé A, Allaire A, Labbé SM, Serdjebi C, Barbier O, Caron A. , DOI 10.1016/j.yexmp.2025.104996

Ablation of Sympathetic Nerve-β3 Adrenergic Receptor-mediated Adipose Tissue Lipolysis Attenuates Alcohol-induced Liver Injury in Mice., Cellular and molecular gastroenterology and hepatology, 2025. Wickramasinghe PB, Caron A, Parupalli P, Liu J, Eadha S, Ganapavarapu S, Elmquist JK, Liu C, Jia L. , DOI 10.1016/j.jcmgh.2025.101623

Pharmaco-nutraceutical improvement of the response to obeticholic acid with omega-3 polyunsaturated fatty acids., The Biochemical journal, 2025. Lavoie AA, Thérien A, Silva A, Paré E, Ciešlak A, Gagnon W, Desjardins C, Verreault M, Trottier J, Vohl MC, Drouin-Chartier JP, Corbeil J, Caron A, Barbier O. , DOI 10.1042/bcj20253113

Cold Exposure Exacerbates Cardiac Dysfunction in a Model of Heart Failure with Preserved Ejection Fraction in Male and Female C57Bl/6J Mice, Biomedicines, 2025. Thibodeau S, Legros M, Labbé E, Walsh-Wilkinson É, Morin-Grandmont A, Arsenault M, Caron A, Couet J, Beji S.

Cold Exposure Exacerbates Cardiac Dysfunction in a Model of Heart Failure with Preserved Ejection Fraction in Male and Female C57Bl/6J Mice., Biomedicines, 2025. Thibodeau SÈ, Legros ML, Labbé EA, Walsh-Wilkinson É, Morin-Grandmont A, Beji S, Arsenault M, Caron A, Couet J. , DOI 10.3390/biomedicines13081900

New players in the leptin orchestra: PNOC/NPY neurons tune appetite and obesity, Neuron, 2025. Olivier Lavoie, Natalie J. Michael, Alexandre Caron. DOI 10.1016/j.neuron.2025.05.026

The long non-coding RNA<i>TRIB1AL</i>links metabolic dysfunction-associated steatotic liver disease, cardiometabolic risk and human lifespan 2025. Gobeil É, Bourgault J, Gagnon E, Samson N, Ruel L, Côté V, Mitchell PL, Couture C, Gotti C, Roux-Dalvai F, Droit A, Bossé Y, Mathieu P, Arsenault BJ. , DOI 10.1101/2025.06.11.25329423

Spontaneous and pharmacologically induced hypothermia protect mice against endotoxic shock, British Journal of Pharmacology, 2025. Tinajero, A., Merchant, W., Khan, A., Surbhi, Caron, A., Reynolds, R., Jia, L., Gautron, L.. DOI 10.1111/bph.70000

Liver adrenoceptor alpha-1b plays a key role in energy and glucose homeostasis in female mice, American Journal of Physiology-Endocrinology and Metabolism, 2024. Anisia Silva, Mathilde Mouchiroud, Olivier Lavoie, Sarra Beji, Joel K. Elmquist, Alexandre Caron. DOI 10.1152/ajpendo.00153.2024

A sympathetic paradigm shift for the role of NPY in obesity, Cell Metabolism, 2024. Olivier Lavoie, Alexandre Caron. DOI 10.1016/j.cmet.2024.10.010

Ablation of sympathetic nerve-β3 adrenergic receptor-mediated adipose tissue lipolysis attenuates alcohol-induced liver injury in mice, bioRxiv, 2024. Wickramasinghe, P., Caron, A., Eadha, S., Parupalli, P., Ganapavarapu, S., Elmquist, J., Liu, C., Jia, L.. DOI 10.1101/2024.12.08.627372

Unveiling a novel memory center in human brain: neurochemical identification of the nucleus incertus, a key pontine locus implicated in stress and neuropathology, Biological Research, 2024. de Ávila, C., Gugula, A., Trenk, A., Intorcia, A.J., Suazo, C., Nolz, J., Plamondon, J., Khatri, D., Tallant, L., Caron, A., Blasiak, A., Serrano, G.E., Beach, T.G., Gundlach, A.L., Mastroeni, D.F.. DOI 10.1186/s40659-024-00523-z

The effects of the β₁-adrenergic receptor antagonist bisoprolol administration on mirabegron-stimulated human brown adipose tissue thermogenesis, Acta Physiologica, 2024. Dumont, L., Caron, A., Richard, G., Croteau, E., Fortin, M., Frisch, F., Phoenix, S., Dubreuil, S., Guérin, B., Turcotte, É.E., Carpentier, A.C., Blondin, D.P.. DOI 10.1111/apha.14127

HSDL2 links nutritional cues to bile acid and cholesterol homeostasis, Science Advances, 2024. Samson, N., Bosoi, C.R., Roy, C., Turcotte, L., Tribouillard, L., Mouchiroud, M., Berthiaume, L., Trottier, J., Silva, H.C.G., Guerbette, T., Plata-Gómez, A.B., Besse-Patin, A., Montoni, A., Ilacqua, N., Lamothe, J., Citron, Y.R., Gélinas, Y., Gobeil, S., Zoncu, R., Caron, A., Morissette, M., Pellegrini, L., Rochette, P.J., Estall, J.L., Efeyan, A., Shum, M., Audet-Walsh, É., Barbier, O., Marette, A., Laplante, M.. DOI 10.1126/sciadv.adk9681

Metabolism Pharmacology, Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays: Volume 1-3, Third Edition, 2024. Caron, A., Barbier, O., Anhê, F.F., Herling, A.W.. DOI 10.1007/978-3-031-35529-5_66

Hypothalamic GABAergic Neurons Expressing Cellular Retinoic Acid Binding Protein 1 (CRABP1) Are Sensitive to Metabolic Status and Liraglutide in Male Mice, Neuroendocrinology, 2024. Lavoie, O., Turmel, A., Mattoon, P., Desrosiers, W.J., Plamondon, J., Michael, N.J., Caron, A.. DOI 10.1159/000538716

Changes in hypothalamic subunits volume and their association with metabolic parameters and gastrointestinal appetite-regulating hormones following bariatric surgery, medRxiv, 2024. Lachance, A., Daoust, J., Pelletier, M., Caron, A., Carpentier, A.C., Biertho, L., Maranzano, J., Tchernof, A., Dadar, M., Michaud, A.. DOI 10.1101/2024.08.30.24312638

A critical update on the leptin-melanocortin system, Journal of Neurochemistry, 2023. Lavoie, O., Michael, N.J., Caron, A.. DOI 10.1111/jnc.15765

Inhibition of the beta-1 adrenergic receptor does not potentiate mirabegron-stimulated human brown adipose tissue thermogenesis., medRxiv, 2023. Dumont, L., Caron, A., Richard, G., Croteau, E., Fortin, M., Frisch, F., Phoenix, S., Dubreuil, S., Guérin, B., Turcotte, É.E., Carpentier, A.C., Blondin, D.P.. DOI 10.1101/2023.03.22.23287600

Photoperiodic Remodeling of Adiposity and Energy Metabolism in Non-Human Mammals, International Journal of Molecular Sciences, 2023. Navarro-Masip, È., Caron, A., Mulero, M., Arola, L., Aragonès, G.. DOI 10.3390/ijms24021008

DEPTOR loss impairs brown adipocyte development in vitro but has limited impacts in mice, Molecular Metabolism, 2023. Colas, C., Mouchiroud, M., Al Dow, M., Kolnohuz, A., Gélinas, Y., Caron, A., Laplante, M.. DOI 10.1016/j.molmet.2022.101660

Electrophysiological Comparison of Definitive Pro-opiomelanocortin Neurons in the Arcuate Nucleus and the Retrochiasmatic Area of Male and Female Mice, Neuroscience, 2023. Srour, N., Lavoie, O., Khouma, A., Minbashi Moeini, M., Plamondon, J., Kinkead, R., Michael, N.J., Caron, A.. DOI 10.1016/j.neuroscience.2023.08.024

Unveiling a Novel Memory Center in Humans: Neurochemical Identification of the Nucleus Incertus, a Key Pontine Locus Implicated in Stress and Neuropathology, bioRxiv, 2023. de Ávila, C., Gugula, A., Trenk, A., Intorcia, A.J., Suazo, C., Nolz, J., Plamondon, J., Khatri, D., Tallant, L., Caron, A., Błasiak, A., Serrano, G.E., Beach, T.G., Gundlach, A.L., Mastroeni, D.F.. DOI 10.1101/2023.09.08.556922

Histaminergic regulation of food intake, Frontiers in Endocrinology, 2023. Khouma, A., Moeini, M.M., Plamondon, J., Richard, D., Caron, A., Michael, N.J.. DOI 10.3389/fendo.2023.1202089

Do POMC neurons have a sweet tooth for leptin? Special issue: Role of nutrients in nervous control of energy balance, Biochimie, 2022. Nader Srour, Alexandre Caron, Natalie Jane Michael. DOI 10.1016/j.biochi.2022.09.006

The sympathetic nervous system in the 21st century: Neuroimmune interactions in metabolic homeostasis and obesity, Neuron, 2022. Martinez-Sanchez, N., Sweeney, O., Sidarta-Oliveira, D., Caron, A., Stanley, S.A., Domingos, A.I.. DOI 10.1016/j.neuron.2022.10.017

CB1Rs in VMH Neurons Regulate Glucose Homeostasis but not Body Weight, American Journal of Physiology-Endocrinology and Metabolism, 2021. DOI 10.1152/ajpendo.00044.2021

New Horizons: Is Obesity a Disorder of Neurotransmission?, Journal of Clinical Endocrinology and Metabolism, 2021. Caron, A., Jane Michael, N.. DOI 10.1210/clinem/dgab421

Pathophysiological Mechanisms That Alter the Autonomic Brain-Liver Communication in Metabolic Diseases, Endocrinology (United States), 2021. Silva, A., Caron, A.. DOI 10.1210/endocr/bqab164